Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection
Identifieur interne : 001150 ( Main/Exploration ); précédent : 001149; suivant : 001151Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection
Auteurs : Oi-Wing Ng [Singapour] ; Adeline Chia [Singapour] ; Anthony T. Tan [Singapour] ; Ramesh S. Jadi [Singapour] ; Hoe Nam Leong [Singapour] ; Antonio Bertoletti [Singapour] ; Yee-Joo Tan [Singapour]Source :
- Vaccine [ 0264-410X ] ; 2016.
Descripteurs français
- KwdFr :
- Antigènes d'histocompatibilité de classe I (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient, Déterminants antigéniques des lymphocytes T (immunologie), Humains, Immunité cellulaire, Lymphocytes T CD8+ (immunologie), Mémoire immunologique, Protéines de la matrice virale (immunologie), Protéines nucléocapside (immunologie), Réactions croisées, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Virus du SRAS.
- MESH :
- immunologie : Antigènes d'histocompatibilité de classe I, Déterminants antigéniques des lymphocytes T, Lymphocytes T CD8+, Protéines de la matrice virale, Protéines nucléocapside, Syndrome respiratoire aigu sévère.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Immunité cellulaire, Mémoire immunologique, Réactions croisées, Syndrome respiratoire aigu sévère, Virus du SRAS.
English descriptors
- KwdEn :
- CD8-Positive T-Lymphocytes (immunology), Cross Reactions, Epitopes, T-Lymphocyte (immunology), Histocompatibility Antigens Class I (immunology), Humans, Immunity, Cellular, Immunologic Memory, Middle East Respiratory Syndrome Coronavirus, Nucleocapsid Proteins (immunology), SARS Virus, Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Viral Matrix Proteins (immunology).
- MESH :
- chemical , immunology : Epitopes, T-Lymphocyte, Histocompatibility Antigens Class I, Nucleocapsid Proteins, Viral Matrix Proteins.
- immunology : CD8-Positive T-Lymphocytes, Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- Cross Reactions, Humans, Immunity, Cellular, Immunologic Memory, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
Abstract
Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus (SARS-CoV). The virus is believed to have originated from bats and transmitted to human through intermediate animals such as civet cats. The re-emergence of SARS-CoV remains a valid concern due to the continual persistence of zoonotic SARS-CoVs and SARS-like CoVs (SL-CoVs) in bat reservoirs. In this study, the screening for the presence of SARS-specific T cells in a cohort of three SARS-recovered individuals at 9 and 11 years post-infection was carried out, and all memory T cell responses detected target the SARS-CoV structural proteins. Two CD8+ T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions. Furthermore, these responses were found to persist up to 11 years post-infection. An absence of cross-reactivity of these CD8+ T cell responses against the newly-emerged Middle East respiratory syndrome coronavirus (MERS-CoV) was also demonstrated. The knowledge of the persistence of SARS-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable.
Url:
DOI: 10.1016/j.vaccine.2016.02.063
PubMed: 26954467
PubMed Central: 7115611
Affiliations:
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Ng</name><affiliation wicri:level="4"><nlm:aff id="aff0005">Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Chia, Adeline" sort="Chia, Adeline" uniqKey="Chia A" first="Adeline" last="Chia">Adeline Chia</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Anthony T" sort="Tan, Anthony T" uniqKey="Tan A" first="Anthony T." last="Tan">Anthony T. Tan</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Duke-NUS Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Jadi, Ramesh S" sort="Jadi, Ramesh S" uniqKey="Jadi R" first="Ramesh S." last="Jadi">Ramesh S. 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A" first="Antonio" last="Bertoletti">Antonio Bertoletti</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School</wicri:regionArea><wicri:noRegion>Duke-NUS Graduate Medical School</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0020">Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*STAR), Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*STAR)</wicri:regionArea><wicri:noRegion>Agency of Science Technology and Research (A*STAR)</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name><affiliation wicri:level="4"><nlm:aff id="aff0005">Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0025">Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)</wicri:regionArea><wicri:noRegion>Technology and Research)</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Cross Reactions</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Histocompatibility Antigens Class I (immunology)</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunologic Memory</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Nucleocapsid Proteins (immunology)</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Viral Matrix Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I (immunologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Humains</term><term>Immunité cellulaire</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Mémoire immunologique</term><term>Protéines de la matrice virale (immunologie)</term><term>Protéines nucléocapside (immunologie)</term><term>Réactions croisées</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>Histocompatibility Antigens Class I</term><term>Nucleocapsid Proteins</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I</term><term>Déterminants antigéniques des lymphocytes T</term><term>Lymphocytes T CD8+</term><term>Protéines de la matrice virale</term><term>Protéines nucléocapside</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cross Reactions</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunologic Memory</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Immunité cellulaire</term><term>Mémoire immunologique</term><term>Réactions croisées</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus (SARS-CoV). The virus is believed to have originated from bats and transmitted to human through intermediate animals such as civet cats. The re-emergence of SARS-CoV remains a valid concern due to the continual persistence of zoonotic SARS-CoVs and SARS-like CoVs (SL-CoVs) in bat reservoirs. In this study, the screening for the presence of SARS-specific T cells in a cohort of three SARS-recovered individuals at 9 and 11 years post-infection was carried out, and all memory T cell responses detected target the SARS-CoV structural proteins. Two CD8<sup>+</sup> T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions. Furthermore, these responses were found to persist up to 11 years post-infection. An absence of cross-reactivity of these CD8<sup>+</sup> T cell responses against the newly-emerged Middle East respiratory syndrome coronavirus (MERS-CoV) was also demonstrated. The knowledge of the persistence of SARS-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D. Erdman</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T. Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S. Emery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. 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Enama</name></author><author><name sortKey="Larkin, B D" uniqKey="Larkin B">B.D. Larkin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Singapour</li></country><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="Singapour"><noRegion><name sortKey="Ng, Oi Wing" sort="Ng, Oi Wing" uniqKey="Ng O" first="Oi-Wing" last="Ng">Oi-Wing Ng</name></noRegion><name sortKey="Bertoletti, Antonio" sort="Bertoletti, Antonio" uniqKey="Bertoletti A" first="Antonio" last="Bertoletti">Antonio Bertoletti</name><name sortKey="Bertoletti, Antonio" sort="Bertoletti, Antonio" uniqKey="Bertoletti A" first="Antonio" last="Bertoletti">Antonio Bertoletti</name><name sortKey="Chia, Adeline" sort="Chia, Adeline" uniqKey="Chia A" first="Adeline" last="Chia">Adeline Chia</name><name sortKey="Jadi, Ramesh S" sort="Jadi, Ramesh S" uniqKey="Jadi R" first="Ramesh S." last="Jadi">Ramesh S. Jadi</name><name sortKey="Leong, Hoe Nam" sort="Leong, Hoe Nam" uniqKey="Leong H" first="Hoe Nam" last="Leong">Hoe Nam Leong</name><name sortKey="Tan, Anthony T" sort="Tan, Anthony T" uniqKey="Tan A" first="Anthony T." last="Tan">Anthony T. Tan</name><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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